1555 de teste nursing pdf. Since the first report decades ago, proteolysis has been found in a broad spectrum of eukaryotic organisms. Given the importance of histone modifications in epigenetic regulation we further elaborate on the different ways in which histone proteolysis could play a role in epigenetics. Finally, unanticipated histone proteolysis has probably left a mark on many studies of histones in the past. Our initial observation is that these two different classes are very hard to distinguish both experimentally and biologically, because they can both be mediated by the same enzymes. However, the authors often not clearly distinguish or determine whether degradation or clipping was studied.

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